https://variagenome.com/the-variant Plain-language genomic explainers and research surveys from Varia. en-us Wed, 17 Jun 2026 12:00:00 GMT https://variagenome.com/the-variant/factor-v-leiden-explained https://variagenome.com/the-variant/factor-v-leiden-explained A plain-language explainer of Factor V Leiden (rs6025), the most common inherited blood-clotting variant, which Varia reads from your raw DNA file under Heart and Lipids. Mon, 15 Jun 2026 12:00:00 GMT 2026-06-17T12:00:00Z https://variagenome.com/the-variant/polygenic-risk-scores-explained https://variagenome.com/the-variant/polygenic-risk-scores-explained Polygenic risk scores are having a moment in consumer genomics. Here is what the published evidence actually supports, where they help, and why Varia explains them without ever printing a personal risk number. Wed, 10 Jun 2026 12:00:00 GMT 2026-06-17T12:00:00Z https://variagenome.com/the-variant/mthfr-explained https://variagenome.com/the-variant/mthfr-explained A plain-language explainer of the two common MTHFR variants, C677T (rs1801133) and A1298C (rs1801131), in the folate-processing gene, which Varia reads under Metabolism and Longevity. Sun, 07 Jun 2026 12:00:00 GMT 2026-06-17T12:00:00Z https://variagenome.com/the-variant/comt-val158met-research-watch https://variagenome.com/the-variant/comt-val158met-research-watch A plain-language survey of COMT Val158Met (rs4680), one of the most studied and most over-interpreted common variants in behavioral genetics. It is not in the Varia Genome Catalog, and this post explains why the evidence reads as open questions rather than conclusions. Wed, 03 Jun 2026 12:00:00 GMT 2026-06-17T12:00:00Z https://variagenome.com/the-variant/apoe-e4e4-genotype https://variagenome.com/the-variant/apoe-e4e4-genotype A plain-language explainer of the APOE e4/e4 diplotype, the highest common genetic risk configuration for late-onset Alzheimer's disease in Varia's curated catalog. Mon, 01 Jun 2026 12:00:00 GMT 2026-06-15T12:00:00Z